Bub1 proliferation

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August undefined, 2024

WebBudding uninhibited by benzimidazoles 1 (BUB1) is a mitotic checkpoint serine/threonine kinase that has been reported as an oncogene or tumor suppressor gene in various … WebOct 21, 2024 · Conclusions: The current study discovered CDC20,BUB1 and CCNB2 as hub-genes associated with Wilms tumor, providing references to understand the pathogenesis and be considered a novel candidate to target therapy and construct novel nomogram, incorporating both clinical risk factors and gene model, could be …

KIF4A knockdown suppresses ovarian cancer cell proliferation and ...

WebSep 23, 2009 · Background Bub1 is a component of the spindle assembly checkpoint, a surveillance mechanism that maintains chromosome stability during M-phase. Bub1 is essential during the early stages of embryogenesis, with homozygous BUB1-null mice dying shortly after day E3.5. Bub1 is also required later during embryogenesis; inactivation of … WebMar 5, 2024 · In summary, the present study demonstrated that BUB1 increased the proliferation of liver cancer cells. These results provided an improved understanding of the mechanisms for the role of BUB1 in … incontinence pads boots chemist

miR-30a-3p can inhibit the proliferation and promote the ...

WebBUB1 and BUBR1 are cell cycle-independent binding partners of BUB3 and are recruited to unattached kinetochores through BUB3. BUBR1:BUB3 may have two pools at KNL1, one dependent on BUB1 and the other independent of BUB1. KNL1 also recruits the Rod-ZW10-Zwilch (RZZ complex) in a BUB1-dependent manner (Zhang et al., 2015 ). WebSep 27, 2024 · The expression of bub1 was found to be able to reduce the immunosuppressive effect of these cancers ( 30 – 33 ). bub1 expression was increased in human bladder cancer (BCa), and bub1 kinase drives the progression and proliferation of BCa by regulating the transcriptional activation of STAT3 signaling ( 34 ). WebFeb 17, 2024 · Bub1 is a conserved kinase critical for the spindle assembly checkpoint. Bub1 also facilitates chromosome alignment and contributes to the regulation of mitotic duration. incontinence pads ebay uk

Prognostic Value of BUB1 for Predicting Non-Muscle-Invasive

WebImmunohistochemistry, qRT-PCR, and Western blot were employed to detect BUB1 and transforming growth factor-beta (TGFβ/Smad) signaling-related proteins expression in … WebBUB1 (BUB1A, BUB1L, hBUB1) protein expression summary. Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly c heckpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization … incontinence pads after birthWebJun 2, 2013 · In vitro BUB1 and BUBR1 inhibition decreases cell proliferation in SF188 cells. BUBR1 and BUB1 inhibition caused a significant (p < 0.05) decrease on pediatric … incontinence pads at walmart

"WebRecombinant Anti-Bub1 antibody [EPR18947] (ab195268) Datasheet SDS Certificate of Compliance Submit a review Submit a question References (5) $605 Product size 100 µl Add to basket Order now and get it on Wednesday March 08, 2024 Custom quote Bulk request Shipping info $50.00 to United States " - Bub1 proliferation

Bub1 proliferation

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WebOverexpression of the mitotic checkpoint genes BUB1, BUBR1, and BUB3 in gastric cancer--association with tumour cell proliferation. The mitotic spindle assembly checkpoint … WebDec 1, 2024 · Finally, BUB1 also enhanced NFATC2- and LHX1-induced BCa cell proliferation mediated by STAT3. A pharmacological inhibitor of BUB1 (2OH-BNPP1) …

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WebBub1 Antibodies. Antibodies that detect Bub1 can be used in several scientific applications, including Western Blot, Immunocytochemistry, ELISA, Immunohistochemistry and … WebAug 1, 2024 · Furthermore, BUB1 overexpression was closely associated with the poor clinical outcomes of patients with OS. Inhibition of BUB1 markedly suppressed cell …

WebThe data showed that tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma ( YWHAG ), BUB1 mitotic checkpoint serine/threonine kinase ( BUB1 ), and growth arrest and DNA damage-inducible 45 ( GADD45) genes were enriched in the cell cycle pathway. 6. WebFeb 15, 2024 · BAY 1816032 was characterized for kinase selectivity, inhibition of BUB1 signaling, and inhibition of tumor cell proliferation alone and in combination with taxanes, …

WebJan 15, 2024 · βArr1 or βArr2 are regulated in breast tumours To determine the clinical significance of the two βArrs we explored the expression profiles of these two genes in TCGA breast tissue data set 35. The... WebFeb 1, 2006 · The proliferation signature is now commonly associated with the expression of a core set of genes ( MYBL2, BUB1 and polo-like kinase 1 ( PLK1 )), along with other cell-cycle-regulated genes...

WebDec 1, 2024 · Conclusion: This study showed that the BUB1 kinase drives the progression and proliferation of BCa by regulating the transcriptional activation of STAT3 signaling …

To further explore the relationship between BUB1 and STAT3 in BCa, we examined whether BUB1 regulates the activation of STAT3 by phosphorylation. First, an in vitro kinase assay was performed in 5637 cells. We incubated purified recombinant human BUB1 protein with purified STAT3 protein and H2A histone … See more The functions of BUB1 during the progression and carcinogenesis of BCa are not fully understood. Comprehensive analysis of the … See more The BUB1 kinase protein contains multiple functional domains (Fig. 3A). Gang et al.’s SALIC proteomic data showed that BUB1 interacted with STAT [27]. To observe whether native BUB1 … See more To understand the biological significance of BUB1-mediated phosphorylation and the effects of BUB1 on the occurrence and progression of BCa, we investigated the transcriptomes of … See more To confirm this conclusion, we performed qRT–PCR by knocking down BUB1 with siRNA, and the results showed that the transcriptional activity of STAT3 was reduced significantly and that the expression of STAT3 … See more incontinence pads for mattressWebBub1 Gene Detail Summary Symbol Bub1 Name BUB1, mitotic checkpoint serine/threonine kinase Synonyms Bub1a, D2Xrf87 Feature Type protein coding gene IDs MGI:1100510 NCBI Gene: 12235 Alliance gene page Transcription Start Sites 2 TSS Location & Maps more Sequence Map Chr2:127643036-127673785 bp, - strand From … incontinence pads for catsWebFirst, the irradiation treatment showed greater cytotoxicity for in vitro cell growth when combined with BUB1 inhibitor. Second, the FACS data showed that the combination of … incontinence pads for men at saversWebDec 15, 2024 · Bub1 has a Bub3-binding domain through which Bub1 is localized to kinetochores . The Bub1 central region acts as a scaffold for Bub1-mediated localization … incontinence pads on prescription for menWebJan 4, 2013 · Mitotic checkpoint is a fundamental mechanism involved in fidelity mitotic chromosome segregation, and its alteration results in progression of human malignancies. In this study, we examined expression profiles of seven mitotic checkpoint genes in 20 breast carcinomas using microarray analysis. Results demonstrated that BUB1 expression level … incontinence pads for men asdaWebFeb 13, 2012 · Anti-Bub1 antibody [EPR18947] (ab195268) Research with confidence – consistent and reproducible results with every batch Long-term and scalable supply – … incontinence pads for kidsWebBub1 is an evolutionarily conserved mitotic checkpoint control protein that is present in diverse organisms including yeast and humans. Bub1 is a serine/threonine protein kinase and is required for recruitment of Mad1, Mad2, Bub3, and CENP-E to kinetochores. incontinence pads for car seats